ILC 2022 Basic Science Seminar:
"Emerging concepts in liver metabolism"
The two-day Basic Science Seminar at ILC 2022 will focus on the central role of the liver being a site of increasingly common metabolic disorders related to hepatic fat accumulation. From a macroscopic to a microscopic point of view the seminar aims to send us on a journey exploring organ crosstalk and multicellular communication that drives metabolic diseases. The various expertise of speakers will not only highlight the pathways impaired in fatty liver disease but that also provide novel potential therapeutic strategies for this disease.
The seminar aims to foster the interaction between leaders-in-the-field and the audience. It contains multiple short duo-lectures, with first a more general 10-minutes overview into the topic, followed by a more in-depth 10-minutes presentation by a talented fellow and finally an extensive Q&A of 10 minutes. In total 5 such sessions will extensively cover the field of fatty liver disease and associated complications such as fibrosis and cancer.
The program is attractive to both professionals from the basic science field as well as to clinicians who would like to improve their understanding of the mechanisms underlying disease and of potential future therapeutic targets.
- To understand the relevance and regulation of organ crosstalk in liver metabolism
- To understand the pivotal role of metabolism in liver cancer
- To get to know the intricate cellular interactions and metabolic drivers that govern inflammation in the liver
- To learn the role and regulation by the nervous system in the control of the hepatic and systemic metabolism
- To understand how liver metabolism dyregulation could lead to fibrosis
Myriam Aouadi received her PhD from the University Côte d'Azur, Nice, France, where she studied adipose tissue expansion using embryonic and adult stem cells. Her lab investigates the roles of macrophages in metabolic diseases with a particular focus on hepatic macrophages in non-alcoholic fatty liver disease (NAFLD).
Stan van de Graaf
Stan van de Graaf is Professor of Experimental Hepatology and Metabolism at Amsterdam University Medical Centers and group leader at Tytgat Institute for Liver and Intestinal Research. His main research interests are metabolic and cholestatic liver diseases with a focus on transport and signaling processes.
Mathias Heikenwaelder is a trained molecular biologist and microbiologist, with expertise in immunology, pathology and a strong link to translational research evoked by 10 years of work and expertise in a Pathology Institution (Clinical Pathology, University Hospital Zurich, Switzerland).