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Clinical Practice Guidelines

Management of Hepatitis C Virus Infection

Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The long-term impact of HCV infection is highly variable, from minimal changes to extensive fibrosis and cirrhosis with or without hepatocellular carcinoma (HCC). The number of chronically infected persons worldwide is estimated to be about 160 million, but most…
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ESPGHAN Clinical Practice Guidelines: Management of chronic hepatitis B in childhood

More than 360 million persons worldwide (6% of the world population) are chronically infected by the hepatitis B virus (HBV). Although the incidence of HBV infection has dramatically declined since the implementation of universal immunization programs in several countries and blood-donor screening, a significant number of children are still infected each year, often developing chronic infection…
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Management of Alcoholic Liver Disease

Alcoholic liver disease (ALD) is the most prevalent cause of advanced liver disease in Europe. However, there has been limited research investment into ALD despite its significant burden on the health of Europeans. This disparity is reflected by the ETOh score – the ratio of the estimated population mortality rate to the number of trials…
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EASL-EORTC Clinical Practice Guidelines: Management of Hepatocellular Carcinoma

These guidelines result from a joint collaboration between the European Association for the Study of the Liver (EASL) and the European Organization for Research and Treatment of Cancer (EORTC). The EASL–EORTC Clinical Practice Guidelines provide common guidelines for the management of hepatocellular carcinoma (HCC) and define the use of surveillance, diagnosis, and therapeutic strategies recommended…
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Management of Chronic Hepatitis B 2012 Revised Version

April 2012, EASL’s revised CPGs on the Management of Chronic Hepatitis B (originally released in October 2008) now include; modified indications for liver biopsy and treatment for HBeAg-negative patients, new stopping rules for pegylated interferon-alfa therapy, amended recommendations for patients with partial virological response at 12 months of therapy with entecavir (ETV) or tenofovir (TDF),…
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Management of Wilson’s Disease

Recommendations are based on a systematic literature review in the Medline (PubMed version), Embase (Dialog version), and the Cochrane Library databases using entries from 1966 to 2011. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system used in other EASL CPGs was used and set against the somewhat different grading system used in the…
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Management of Hepatitis C Virus Infection

Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The long-term hepatic impact of HCV infection is highly variable, from minimal changes to chronic hepatitis, extensive fibrosis, and cirrhosis with or without hepatocellular carcinoma (HCC). The number of chronically infected persons worldwide may exceed 200 million, but most…
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Management of Ascites, Spontaneous Bacterial Peritonitis, and Hepatorenal Syndrome in Cirrhosis

EASL has published clinical practice guidelines for the management of ascites, the most common complication of cirrhosis. The peer-reviewed guidelines are available in the September 2010 issue, (Volume 53, No.3) of the Journal of Hepatology and online CPGs. They will also provide recommendations for the management of spontaneous bacterial peritonitis (SBP) and hepatorenal syndrome, which…
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Management of HFE Hemochromatosis

EASL is pleased to announce the publication of its 3rd Clinical Practice Guidelines on the Management of HFE Hemochromatosis (HFE-HC). 1 in 200 people in northern Europe are affected by hemochromatosis, a highly prevalent but somewhat overlooked disease due to its lack of symptoms and difficult diagnosis, making it one of the most common inheritable…
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Management of Cholestatic Liver Diseases

In October 2008, EASL proudly published its first CPG on the Management of Chronic Hepatitis B. Eight months later, new subject matter was published in the same series of Clinical Practice Guidelines; this time on the Management of Cholestatic Liver Diseases.
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