- Prof. Valérie Paradis, France
- Prof. Peter Schirmacher, Germany
- Prof. Christine Sempoux, Switzerland
- Prof. Joanne Verheij, The Netherlands
Program Overview / Summary
Inflammatory liver diseases: new developments, new challenges
With the endorsement of the European Society of Pathology (ESP)
The role of liver biopsy in inflammatory liver diseases has undergone major changes over the past decades. Clinical tests, non-invasive techniques, and imaging have improved. Since the indication for liver biopsies has changed, the number of liver biopsies in certain indications, like in viral hepatitis, has decreased. For many liver diseases, such as NAFLD, liver biopsy represents the gold standard. Yet the majority of patients with NAFLD will never undergo a biopsy. A liver biopsy is typically part of the initial diagnostic work-up for the diagnosis of auto-immune hepatitis.
For biliary diseases, however, a biopsy is not required for diagnosis. In these patients, histology may be very informative in ruling out concomitant auto-immune hepatitis or other liver diseases. New drugs, including immunotherapeutic agents in the field of oncology, may be associated with variable liver toxicities encountered and discovered. Despite infectious diseases of the liver being among the most prevalent health problems worldwide, biopsy strategies remain variable and changing.
When a liver biopsy is considered for diagnostic purposes, the major question is the benefit of the information the biopsy reveals, including the added value of the biopsy for the different diseases versus using non-invasive tests. These considerations are the main focus of this EASL School. The participants are invited to grade and stage different liver diseases, and to discuss the relevant scoring systems.
Each disease will be tackled from both a clinical point of view and from the perspective of the pathologist, focusing on criteria for diagnosis and possible pitfalls. The interaction between these partners is key, through this course and in daily practice.
About the Pathology School
Relevant literature (pre-reading material, including scientific articles) will be provided to the participants before the meeting. Hand-outs will be provided after the course.
Clinical cases, including digitised biopsies, will be available before the start of the School.
During the meeting, complementary clinical and pathological talks will address relevant topics, with a general clinical introduction and followed by plenary discussions.
Clinical cases will be discussed per theme to illustrate the importance of clinico-pathological correlation, to discuss the role of the liver biopsy and the grading and staging of the different liver diseases.
Workshops, including slides sessions, will be planned to illustrate the morphological spectrum of inflammatory liver diseases.
Participants can supply interesting cases from their own institution (making them available before the start of the course to discuss during the workshop sessions).
A quiz application (via mobile phone) will be used to ensure interactive contribution of the participants.
- Ulrich Beuers (Amsterdam, The Netherlands)
- Joep de Bruijne (Utrecht, The Netherlands)
- Otto van Delden (Amsterdam, The Netherlands)
- Joost Drenth (Nijmegen, The Netherlands)
- Onno Holleboom (Amsterdam, The Netherlands)
- Peter Jansen (Amsterdam, The Netherlands)
- Jeroen van der Laak (Nijmegen, The Netherlands)
- Valérie Paradis (Paris, France)
- Cyriel Ponsioen (Amsterdam, The Netherlands)
- Peter Schirmacher (Heidelberg, Germany)
- Christine Sempoux (Lausanne, Switzerland)
- Bart Takkenberg (Amsterdam, The Netherlands)
- Joanne Verheij (Amsterdam, The Netherlands)
- Sophie Willemse (Amsterdam, The Netherlands)
About EASL Schools
The schools contribute to the training of new generations of hepatologists and are a major element of our association. Aimed at young fellows enrolled in hepatology-oriented departments or more experienced clinicians who want to be exposed to the newest trends in hepatology.
For selected applicants, EASL will cover transportation costs to attend the school and accommodation during the event (details will be provided individually once the selection process has been done).
Application is open to young fellows under the age of 35 (born after 3 July 1986) and/or still in training.
Approximately 30 places are available for each school and only EASL members are allowed to apply. Become an EASL member