Rare Liver Diseases are of increasing importance, and contribute a relevant proportion of the hepatological workload, especially in tertiary care centers. Care for Rare Liver Disease, like other liver disease, can only be provided with sufficient background knowledge and experience, which is very difficult to acquire in daily practice due to the relatively rarity of the respective disease. The School for Rare Liver Disease aims at improving clinical knowledge for both paediatric and adult hepatologists, addressing particularly issues of transitional care such as paediatric liver transplant recipients becoming adults. In addition, organisation issues such as referral centers and the opportunities and chances through the new European Reference Network RARE LIVER will be discussed.