DECISION Project: Discover the Full Video Series on Key Research Findings
EASL is proud to support the DECISION project and its mission to advance understanding of decompensated cirrhosis and acute-on-chronic liver failure (ACLF). As part of its dissemination activities, DECISION has released a series of short educational videos highlighting key scientific discoveries from the project.
The videos translate complex research into accessible insights for clinicians, researchers, healthcare professionals, and anyone interested in liver disease research.
DECISION Project: Advancing Treatment Strategies for Decompensated Cirrhosis
This introductory video presents the goals of the DECISION project and its collaborative approach to improving outcomes for patients with advanced liver disease. By leveraging large, well-characterised patient cohorts and innovative translational research, DECISION aims to identify prognostic markers, develop personalised treatment strategies, and reduce the risk of short-term mortality in patients with decompensated cirrhosis.
When Immune Cells Run Empty: Single-Cell Insights in Liver Disease
Presented by Dr Theresa Wirtz
This video explores how single-cell analysis has revealed profound metabolic dysfunction in monocytes, a key group of immune cells, before organ failure becomes clinically apparent in cirrhosis. The findings suggest that immune failure develops gradually and may offer opportunities for earlier intervention.
Epigenetic ‘Switches’ in Cirrhosis: How DNA Methylation Shapes Disease Progression
Presented by Dr Estefanía Huergo Iglesias
Discover how epigenetic mechanisms, particularly DNA methylation, influence disease progression in patients with acute decompensation of cirrhosis. The study identifies molecular signatures associated with poor outcomes and highlights the potential of epigenetic markers for risk stratification.
A Standardised Rapid Animal Model for MASLD/MASH with Translational Potential
Presented by Dr Frank Erhard Uschner
This video introduces a rapid and reproducible animal model that replicates key features of MASLD and MASH within eight weeks. The model provides an important tool for preclinical research and may help accelerate the development of new therapies for metabolic liver disease.
Tiny Messengers, Big Impact: Large Extracellular Vesicles in Acute Liver Decompensation
Presented by Dr Shantha Valainathan
Large extracellular vesicles released by stressed cells may hold valuable clues about disease severity. This research identifies a protein signature that improves prediction of short-term mortality when combined with existing clinical scoring systems, supporting more accurate risk assessment.
Emergency Granulopoiesis in Liver Failure: When the Immune System Goes into Chaos
Presented by Ferran Aguilar Parera
This video examines emergency granulopoiesis, the body’s rapid production of immune cells during severe illness. The findings reveal how disruptions in this process can contribute to immune dysfunction and worsening liver failure, opening new avenues for therapeutic intervention.
ClustALL: Stratifying Decompensated Cirrhosis Patients
Presented by Sara Palomino
Learn about ClustALL, an innovative patient stratification tool that uses unsupervised clustering to identify clinically relevant patient subgroups. The approach supports personalised management of acutely decompensated cirrhosis and is available through an easy-to-use online calculator.
DECISION is a European research initiative dedicated to improving the understanding of the mechanisms driving decompensated cirrhosis and progression to acute-on-chronic liver failure. By combining clinical data, molecular profiling, systems biology, and translational research, the consortium seeks to develop innovative prognostic tools and personalised therapeutic approaches that can improve patient care and reduce mortality in advanced liver disease.
The project brings together leading clinical and research institutions across Europe, working collaboratively to transform scientific discoveries into meaningful benefits for patients.
Explore the full video playlist and learn more about the latest advances emerging from the DECISION consortium.