Spontaneous bacterial peritonitis (SBP) remains a major complication of cirrhosis—but rising antimicrobial resistance and emerging data are challenging long-standing practices.

In this episode, we review current evidence on primary and secondary prophylaxis, resistance patterns, albumin use, and treatment strategies. How should clinicians balance prevention with antimicrobial stewardship? And where might practice need to evolve in 2026?

With Thomas Marjot (Host), Bogdan Procopet (Faculty) and Alastair O’Brien (Faculty)