17 Apr, 2025 - MICROB-PREDICT

MICROB-PREDICT related activities at EASL Congress 2025

22 European institutions join forces in MICROB-PREDICT to improve the prevention and treatment of chronic liver disease (cirrhosis). We aim to identify microbiome-based biomarkers and mechanisms that predict in advance when the body can no longer compensate for the dysfunctional liver (decompensated cirrhosis), when such decompensated cirrhosis will progress to acute-on-chronic liver failure (ACLF), and a patient’s individual treatment response. Based on such biomarkers, we strive to develop novel diagnostic tools for earlier and better patient stratification and to establish personalised and effective treatment strategies.

Wednesday 7 May

When	Where	What
08:30-17:00	Poster area (also available as ePoster)	POSTER ID WED-194-YI Treatment response to Terlipressin in patients with acute kidney injury – hepatorenal syndrome and preexisting chronic kidney disease – the German liver cirrhosis / CKD-Terli study group Presenter: Frank Erhard Uschner (UM) Part of: Cirrhosis and its complications – Portal Hypertension (Topic: “Cirrhosis & Complications”)
08:30-17:00	Poster area (also available as ePoster)	POSTER ID WED-239 Prognostic performance of MELD variants and CLIF-C AD in 958 patients with cirrhosis and ascites Presenter: Nikolaj Torp (OUH) Part of: Cirrhosis and its complications – Portal Hypertension (Topic: “Cirrhosis & Complications”)
14:00-14:30	Cirrhosis & Complications Track Hub	MICROB-PREDICT Networking Session Speakers: Jonel Trebicka (EF CLIF, UM) and consortium partners
08:30-18:00	Poster area	Poster WED-083: Multi-compartment metabolomics for stratifying cirrhotic patients with acute decompensation (Christophe Junot)
17:45-17:50	Arnold Room	Opening remarks - addressing disparities in healthcare in the Netherlands Speaker: Minneke Coenraad (LUMC) Part of: Patient & Advocate Forum: Culturally Competent Care: providing for patients in marginalized communities

Thursday 8 May

When	Where	What
08:30-17:00	Poster area (also available as ePoster)	POSTER ID THU-043 Nuclear factor I-B delays liver fibrosis by inhibiting chemokine ligand 5 transcription Presenter: Qianwen Zhao (UCL) Part of: Fibrosis / Stellate cell biology (Topic “Basic Science”)
08:30-17:00	Poster area (also available as ePoster)	POSTER ID TOP-053 The mechanisms of transcription factor ZEB2 in regulating hepatic stellate cell activation and liver fibrosis Presenter: Qianwen Zhao (UCL) Part of: Fibrosis / Stellate cell biology (Topic “Basic Science”)
08:30-17:00	Poster area (also available as ePoster)	POSTER ID THU-058-YI Blockage of microfibrillar-associated protein 4 (MFAP4) decreases liver fibrosis in two murine models of steatotic liver disease Presenter: Maximilian Joseph Brol (UM) Part of: Fibrosis / Stellate cell biology (Topic “Basic Science”)
08:30-17:00	Poster area (also available as ePoster)	POSTER ID THU-367 Prognosis of primary sclerosing cholangitis (PSC) in Hungary is independent of coexisting inflammatory bowel disease (IBD) and prognostic ability of the currently used PSC risk scores are limited Presenter: David Tornai (UNIDEB) Part of: Immune-mediated and cholestatic disease: Clinical aspects (Topic “Immune-mediated & Cholestatic Diseases”)
09:45-10:30	Track Hub 2 – Basic Science	Poster Tour: Young Investigators – Clinical Chair: Mads Israelsen (OUH)
10:00-10:30	Ring-Larsen Room	Gore & Associates: From Covered TIPS to TIPS using Controlled Expansion Chair: Jonel Trebicka (EF CLIF, UM) Part of: Mini Satellite Symposium (Topic „Cirrhosis & Complications“)
10:30-12:30	De Groote Room	General Session 1 (Abstract Session under the Topic “General Hepatology”) Chair: Aleksander Krag (OUH)
10:00-11:00 12:30-13:30 14:00-15:00 16:15-17:15	Skills Learning Centre 2	EASL/CIRSE Skills Learning Centre: Liver Haemodynamics Chair: Wim Laleman (KUL)
14:00-15:00	Meet-the-Experts 3	Meet-the-Experts: Cutting-edge strategies for biomarker discovery in hepatology Chair: Maja Thiele (OUH)
15:35-15:45	Erlinger Room	Managing financial conflicts of interest Speaker: Rajiv Jalan (UCL) Part of: YI seminar: Science to start-up – Embracing entrepreneurship in hepatology
17:50-18:00	Eddleston Room	Alcohol-related liver disease Speaker: Maja Thiele (OUH) Part of: The JHEP Reports Symposium – Keys to get your manuscript accepted

Friday 9 May

When	Where	What
08:30-09:45	De Groote Room	Future of Hepatology: Novel therapeutics and evolving challenges in managing MASLD Chair: Maja Thiele (OUH)
08:30-09:45	Erlinger Room	EASL/SALVE Symposium: Controversies in the management of patients with alcohol use disorder Chair: Elisa Pose (FCRB)
08:30-17:00	Poster area (also available as ePoster)	POSTER ID FRI-226 The burden of extrahepatic organ failures in European patients with cirrhosis Presenter: Wenyi Gu (UM) Part of: Cirrhosis and its complications: ACLF and Critical illness (Topic “Cirrhosis & Complications”)
08:30-17:00	Poster area (also available as ePoster)	POSTER ID FRI-493 Conversion from standard-release to prolonged-release tacrolimus mitigates calcineurin-induced nephrotoxicity in patients after liver transplantation Presenter: Maximilian Joseph Brol (UM) Part of: Liver transplantation and hepatobiliary surgery – Clinical (Topic “General Hepatology”)
10:00-11:00 12:30-13:30 14:00-15:00 16:15-17:15	Skills Learning Centre 2	EASL/CIRSE Skills Learning Centre: Liver Haemodynamics Chair: Wim Laleman (KUL)
10:30-12:30	De Groote Room	General Session 2 (Abstract Session under the Topic “General Hepatology”) Chair: Debbie Shawcross (KCL)
17:00-18:15	De Groote Room	Abstract Session – Alcohol Chair: Elisa Pose (FCRB)

Saturday 10 May

When	Where	What
08:30-09:45	Ring-Larsen Room	Microbiome and liver health: Unveiling new therapeutic pathways Chair: Debbie Shawcross (KCL)
08:30-16:00	Poster area (also available as ePoster)	POSTER ID SAT-196-YI Prognostic performance of MELD and MELD 3.0 in 777 patients hospitalized with an acute decompensation of cirrhosis Presenter: Nikolaj Torp (OUH) Part of: Cirrhosis and its complications: Other clinical complications except ACLF and critical Illness (Topic: “Cirrhosis & Complications”)
08:30-16:00	Poster area (also available as ePoster)	POSTER ID SAT-210 Development and validation of the modified hepatic encephalopathy staging tool (mHEST) for grading of hepatic encephalopathy for accurate assessment and regulated clinical trials Presenter: Rajiv Jalan (UCL) Part of: Cirrhosis and its complications: Other clinical complications except ACLF and critical Illness (Topic: “Cirrhosis & Complications”)
08:30-16:00	Poster area (also available as ePoster)	POSTER ID SAT-209 Randomized, open-label, phase 2a comparator study to assess the pharmacodynamics, safety and pharmacokinetics of oral administration of mnk6106 (l-ornithine phenylacetate) vs. rifaximin in subjects with hepatic cirrhosis and a previous history of hepatic encephalopathy Presenter: Rajiv Jalan (UCL) Part of: Cirrhosis and its complications: Other clinical complications except ACLF and critical Illness (Topic: “Cirrhosis & Complications”)
09:15-10:00	Industry Workshop	Echosens: MetALD – The role of non-invasive tests Chair: Maja Thiele (OUH)
09:15-09:30	Ring-Larsen Room	Rebooting immunity: Harnessing FMT to revive innate defences in cirrhosis Speaker: Debbie Shawcross (KCL) Part of: Symposium on “Microbiome and liver health: Unveiling new therapeutic pathways”
10:15-11:30	Eddleston Room	YI workshop: How to prepare a Clinical Practice Guideline in Hepatology Chair: Mads Israelsen (OUH)
10:15-11:15	Skills Learning Centre 2	EASL/CIRSE Skills Learning Centre: Liver Haemodynamics Chair: Wim Laleman (KUL)
11:45-12:45	Track Hub 4 – Cirrhosis & complications	Poster tour: Cirrhosis and its complications – Portal Hypertension Chair: Maria Papp (UNIDEB)